Boomer (and MultiForte) Manual - Preface

28 Sep 2005 - Version 3.1.6

David W.A. Bourne

OU College of Pharmacy

P.O. Box 26901

Oklahoma City, OK 73190

U.S.A.

These programs are supplied 'as-is' with no warranty, express or implied. The user must satisfy themselves that correct output is being produced by each program. This is especially important when using user define models, subroutines or batch files. The author can take no responsibility for any of the results from the programs or the use(s) made of the results from these programs. Any decisions based on the output of these programs are the responsibility of the user (not the author).

BOOMER (and MULTIFORTE) are general purpose modeling and simulation programs. They will allow the estimation of parameter values by non-linear weighted least squares regression or the simulation of complex systems of differential equations. Parameter estimation can be by normal or Bayesian methods. Five techniques for approaching the minimum sums of weighted residuals (WSS) are included. These are the Gauss-Newton, Damped Gauss-Newton, Marquardt, Simplex, and the grid search methods. A comprehensive list of weighting schemes is included. The model to be analyzed can be entered as a system of integrated equations or as a system of differential equations. Differential equations are solved by a classical fourth order Runge-Kutta method, a fourth order Runge-Kutta-Gill method, a four/five Runge-Kutta-Fehlberg method, an Adams predictor-corrector method, or Gear's method for stiff equations with or without a PEDERV subroutine. Simulation with random error in parameters or data are also possible. A batch run can be repeated many times to assist in Monte Carlo type studies.

Presently the program has the capacity for 5000 data points, 99 adjustable parameters, 20 lines or sets of data, 999 constants, and 30 differential equations. The Mac OS X Version is written in FORTRAN 77 compiled on an Apple Macintosh^® computer using g77 v3.4.4. The Macintosh version of the program is written in FORTRAN 77 compiled on an Apple Macintosh computer using the Absoft v4.5 (Absoft Corporation, http://www.absoft.com/). The Linux version is written in FORTRAN 77 compiled under Fedora Core 2 using g77. The Windows/DOS version of the program is written in FORTRAN 77 compiled on an Apple Macintosh computer under Microsoft Virtual PC^® v7.0 using g77 v.2.95.

Table of Contents

First Chapter - Chapter 1

This file was last modified: Friday 08 Aug 2008 at 02:01 PM

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