1. With Km = 5 mg/L and Vm = 14 mg/kg/day (wt = 78 kg)
and the required average Cp = 15 mg/L the formula
DoseRate = 819.0 mg/day
2. With two dose rates and plasma concentration values.
| Dose Rate1 | 7 | mg/kg/day |
| Cp1 | 8 | mg/L |
| Dose Rate2 | 10 | mg/kg/day |
| Cp2 | 24 | mg/L |
After solving simultaneous equations the parameters are:
| Km | 6.55 | mg/L |
| Vmax | 12.73 | mg/kg/day |
With these parameters we can calculate the required dose rate:
| Cpreqd | 16 | mg/L |
| Dose Ratereqd | 9.03 | mg/kg/day |
| Dose Ratereqd | 786 | mg/day |