1. Given that Km = 5 mg/L and Vm = 14 mg/kg/day calculate the required daily dose rate to achieve an average plasma concentration of 15 mg/L in a 78 kg patient.
2. A 87 kg patient was given 7 mg/kg/day for some time and the average plasma concentration was measured as 8 mg/L. Since this was too low the dose was raised to 10 mg/kg/day. Unfortunately this resulted in an average plasma concentration of 24 mg/L. Calculate Vm and Km and then calculate a dose rate which should achieve an average plasma concentration of 16 mg/L.