Section ONE. Sketch a Graph or Diagram–Sketch the graphs or diagrams requested in the space provided. Include any distinguishing characteristics. Assume that a linear one compartment model applies unless otherwise specified. Include labels and units. 8 x 3 = 24 points

Q 1.1 Semi-log plot of cumulative amount of unchanged drug into urine versus time after a single IV bolus dose.

Q 1.2 Linear plot of rate of excretion into urine of unchanged drug versus time.

Q 1.3 Sketch the first few steps in the simplex optimization of a two parameter model on a WSS surface.

Q 1.4 Semi-log plot of amount remaining to be excreted as unchanged drug into urine versus time.

Q 1.5 Diagram illustrating a one compartment model after an IV bolus with excretion of unchanged drug and one metabolic pathway for elimination.

Q 1.6 A sketch illustrating Euler's method of numerical integration.

Q 1.7 A sketch illustrating the calculation of AUC between two data points.

Q 1.8 A fluorescence detector labeling three parts of the detector.