PHAR 7632 Spring 1999

Biopharmaceutics

OU HSC College of Pharmacy

Final Exam 5 May 1999 - Answers - Section 2

Section TWO. True/False Check the Correct Response. 8 x 2 = 16 points

Q 2.1 Mathematical models are defined with the SAAM II program using FORTRAN, a computer language. FALSE

Q 2.2 The Nelder-Mead optimization method is a very fast method because it uses complex calculations to move quickly across the WSS surface. FALSE

Q 2.3 The finger print method for back transforming Laplace transforms requires the numerator have a higher power in 's' than the denominator. FALSE

Q 2.4 WinNONLIN can be used to calculate concentration versus time data using given parameter values or to find best values for parameters. TRUE

Q 2.5 Using the 1/Value2 method of weighting means that data points with smaller values are given more emphasis. TRUE

Q 2.6 Appropriate units for Rate of Excretion are mg.hr. FALSE

Q 2.7 The Marquardt method of optimization provides a mix between the Gauss Newton and the steepest descent method. TRUE

Q 2.8 Appropriate units for fe include mg/hr. FALSE