PHAR 7632 Spring 1999

Biopharmaceutics

OU HSC College of Pharmacy

Final Exam 5 May 1999 - Answers - Section 3 Q2

Section THREE Calculations This section = 15 + 25 + 10 + 10 = 60 points

Show all your work for full credit. All material not deleted or crossed-out will be considered for grading. Put labels and units on all graphs.

Q 3.2 (25 points) A 400 mg dose of a drug was given by IV bolus and the data below was collected. Plot the appropriate data on semi-log graph paper, draw the ‘best’ line and determine ke, km, kel, fe, and fm from these data.

Time (hr)
Urine Volume (ml)
Concentration in Urine (µg/ml)
deltaU
(mg)
deltaU/deltat
(mg/hr)
tmidpoint
0
0-1
80
440
35.2
35.2
0.5
1-2
90
370
33.3
33.3
1.5
2-4
190
280
53.2
26.6
3
4-6
170
260
44.2
22.1
5
6-9
Data Lost! oh no!
9-12
300
120
36
12.0
10.5
12-24
1120
60
67.2
5.6
18

Intercept = 37.2 mg/hr = ke • Dose

ke = 37.2 / 400 = 0.093 hr-1

kel = (ln 37.2 - ln 4.12) / 21 = 0.105 hr-1

km = 0.105 - 0.093 = 0.012 hr-1

fe = 0.093 / 0.105 = 0.89

fm = 0.012 / 0.105 = 0.11