HW0103 Answer Question 2

Dose 400 mg  
       
Time Cp delta AUC AUC
hr mg/L   mg.hr/L
0 17.506 0 0
2 14 31.5 31.5
4 11 25.0 56.5
6 9 20.0 76.5
12 4.5 40.5 117.0
Infinity   39.8 156.8
       
kel 0.113 hr-1  
Cp(0) 17.506 mg/L  
       
V 22.8 L  
t(1/2) 6.13 hr  

ChartObject Cp versus Time after 400 mg IV Bolus

The data is consistent with a linear one compartment model because is falls on a straight line on semi-log graph paper.

Last Updated on 1 Mar 2001
By David Bourne
Email: david-bourne@ouhsc.edu