PHAR 7632 Homework #3 2001

One Compartment IV Bolus, Laplace and Various Computer Programs

DUE 27th February 2001

Question 1. Given the following information for a drug which follows linear one compartment pharmacokinetics, calculate Cp at 0.5, 1, 2, 4, and 6 hours after a 250 mg IV bolus dose. Use kel = 0.21 hr-1 ; V = 257 L. Present the data in a table form (with all applicable units) and plot the data on linear and semi-log graph paper. Label the graph and axes appropriately.

Answer

Question 2. Given the following data (Table 1) collected after a 400 mg IV bolus dose, calculate kel, Cp0, V, t1/2, and AUC (using the trapezoidal rule). Verify that the drug follows linear one compartment pharmacokinetics!

Table 1
Time (hr)Concentration (mg/L)
2.0 14.0
4.0 11.0
6.0 9.0
12.0 4.5

Answer

Question 3. Given that a drug follows linear one compartment pharmacokinetics, with kel = 0.075 hr-1 and V = 124 L, calculate a suitable IV bolus dose to maintain plasma concentrations of the drug above 0.24 mg/L for 6 hours. What is the initial plasma concentration?

Answer