PHAR 7632 Homework #4 2001
LaplaceTransforms and Various Computer Programs
DUE 17th April 2001

Question 1. The following data (Table 1) was collected after a 400 mg IV bolus dose.

Table 1

Time (hr) Concentration (mg/L)
2.0

 28.0
4.0

 22.0
6.0

 18.0
12.0

 9.0

Use three programs, from the list: Boomer, SAAM II, WinNONLIN, and ADAPT II to determine best-fit values for V and kel with the data in Table 1. Use a one compartment model with a first order elimiation. Include in your answer, program print-outs including the a) final parameter values and b) a table of observed and calculated data versus time and graphs of a) observed and predicted values versus time and b) weighted residual versus time.

Question 2. ANSWERS Determine if the finger print method can be used to back transform each of the equations. Back transform the equation using this method if possible. If it is not possible explain why (briefly).

a)
b)
c)
d)
e)