If you use the links below make sure you save the page as TEXT with the .BAT extension.
For each numerical method simulate answers using ka equal to 1, 10, 100, or 1000 hr-1. Keep all the other parameters the same. You wil need to edit the .BAT file to change the ka value. Use a text editor if possible. Record your results, either a time for simulation or no answer/error result in tabular form. A slower machine is probably more instructive. Use the same machine for all your runs.
As an answer turn in your table of results and three (only) printouts, one from each numerical integration method.
Question 2. Given that: IV Bolus Dose = 250 mg, ke = 0.087 hr-1, km = 0.021 hr-1, kmu = 0.65 hr-1 calculate cumulative amount excreted as unchanged drug in urine at 0, 2, 4, 6, 9, 12, and 24 hours. Plot your results on linear and semi-log graph paper.
Question 3. Round the numbers you calculated in Question 2 to two digits. For example, take 2.3456 as 2.3 or 0.3456 as 0.35. Now use a nonlinear regression program (Boomer, SAAM II, etc.) to fit these data using two different fitting algorithms. Turn in the two printouts which include final parameter values and a graph of observed and calculated data versus time.
Question 4. Given the following data (Table 1) collected after a 500 mg IV bolus dose, calculate kel, ke, and km. If V = 43.6 L, calculate the renal clearance value.
| Time (hr) | Urine Volume (ml) | Drug Concentration in Urine (mg/L) |
|---|---|---|
| 1 | 80 | 660 |
| 2 | 70 | 600 |
| 4 | 170 | 380 |
| 6 | 170 | 260 |
| 9 | 230 | 180 |
| 12 | 240 | 100 |
| 24 | 890 | 30 |
Question 5. Given the PK model below, derive the integrated equation for Mu1.
The Model: