PHAR 7632 Homework #6 1999
Numerical Integration, Optimization, One Compartment IV Bolus Urine Data, and another Laplace Transform
DUE 27th April 1999
Question 2.
Given that: IV Bolus Dose = 250 mg, ke = 0.087 hr-1, km = 0.021 hr-1, kmu = 0.65 hr-1 calculate cumulative amount excreted as unchanged drug in urine at 0, 2, 4, 6, 9, 12, and 24 hours. Plot your results on linear and semi-log graph paper.
Using the equation: U = (ke*Dose/kel) * [1 - e^(-kel*t)]
Cumulative amount excreted as unchanged drug versus Time
| Time (hr) |
U (mg) |
| 0 |
0 |
| 2 |
39.1 |
| 4 |
70.6 |
| 6 |
96.0 |
| 9 |
125.2 |
| 12 |
146.3 |
| 24 |
186.3 |
