PHAR 7632 Homework #6 1999
Numerical Integration, Optimization, One Compartment IV Bolus Urine Data, and another Laplace Transform
DUE 27th April 1999
Question 4.
Given the following data (Table 1) collected after a 500 mg IV bolus dose, calculate kel, ke, and km. If V = 43.6 L, calculate the renal clearance value.
Table 1
| Time (hr)
| Urine Volume (ml)
| Drug Concentration in Urine (mg/L)
| Delta U
| t(midpoint) (hr)
| deltaU/deltaT (mg/hr)
| U (mg)
|
|---|
| 1 |
80 |
660 |
52.8 |
0.5 |
52.8 |
52.8 |
| 2 |
70 |
600 |
42.0 |
1.5 |
42.0 |
94.8 |
| 4 |
170 |
380 |
64.6 |
3 |
32.3 |
159.4 |
| 6 |
170 |
260 |
44.2 |
5 |
22.1 |
203.6 |
| 9 |
230 |
180 |
41.4 |
7.5 |
13.8 |
245.0 |
| 12 |
240 |
100 |
24.0 |
10.5 |
8.0 |
269.0 |
| 24 |
890 |
30 |
26.7 |
18 |
2.2 |
295.7 |
|
| kel |
0.181 |
hr -1 |
-slope |
| Intercept |
55.248 |
mg/hr |
ke*Dose |
| ke |
0.110 |
hr -1 |
| km |
0.070 |
hr -1 |
kel - km |
| fe |
0.612 |
|
ke/kel |
| V |
43.6 |
L |
| CL r |
4.82 |
L/hr |
ke * V |
| CL r |
80.29 |
ml/min |