Absorption of Different Salt Forms

Fig 4.15.1 Slide showing plasma penicillin concentration versus time curve after oral administration of various salts. The rate at which a drug dissolves is dependent on the solubility of the drug. A common occurrence is that different salts will have quite different solubility characteristics, and again somewhat different to the free acid (or base) form. In the case of penicillin V it appears that only drug which is dissolved quickly can be absorbed.

• Juncher, H. and Raaschou, F. 1957 The solubility of oral preparations of penicillin V, Antibiot. Med. Clin. Therap., 4, 497

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Copyright 2001-3 David W. A. Bourne (david@boomer.org)