IV Bolus One Compartment Model
Student Objectives for this Chapter
- To understand the assumptions associated with the one compartment model
- To understand the properties of first order kinetics and linear models
- To write the differential equations for a simple pharmacokinetic model
- To derive and use the integrated equations for a one compartment linear model
- To define, use, and calculate the parameters, kel (elimination rate constant), t1/2 (half-life), Cl (clearance), V (apparent volume of distribution), and AUC (area under the concentration versus time curve) as they apply to a one compartment linear model
Definition: Pharmacokinetics is the study of drug and/or metabolite kinetics in the body. It deals with a mathematical description of the rates of drug movement into, within and exit from the body. It also includes the study of drug metabolism or biotransformation rates. The body is a very complex system and a drug undergoes many steps as it is being absorbed, distributed through the body, metabolized or excreted (ADME).
Figure 5.1.1 Drug Disposition
The drug also interacts with receptors and causes therapeutic and/or toxic responses. Although the details of drug kinetics are complicated it is fortunate that we can often approximate drug kinetic processes using "simple" mathematical models.
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Copyright 2001-3 David W. A. Bourne (david@boomer.org)
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Tuesday 24 Jun 2003 at 02:13 PM