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IV Bolus - Example 2

We can also calculate the pharmacokinetic parameters kel and V if we know the dose given and the plasma concentrations at two (or more) times after an IV bolus administration. This time we will use Equation 5.12.1

kel from Cp1 and Cp2

Equation 5.12.1 Kel calculated from Two Concentration Values

Question: If Cp2 hours is 4.5 mg/liter and Cp6 hours is 3.7 mg/liter after a 400 mg IV bolus dose what are the values of kel and V.

Now using either the 2 hour or the 6 hour data point calculate the concentration at time zero.

And now

Try your own calculation

IV Bolus Dose:
First concentration:
Time of first Cp value:
Second concentration:
Time of second Cp value:
 
kel is:
t1/2 is:
Cp0 is:
V is:
and Clearance is:
If you get the Error Message Value is not a numeric literal or NaN this probably means that one of the required parameter fields is empty or a value is inappropriate.

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Copyright 2001-3 David W. A. Bourne (david@boomer.org)

This file was last modified: Monday 07 Jul 2003 at 12:08 PM