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IV Bolus - Example 3

Question: What IV bolus dose is required to achieve a plasma concentration of 2.4 µg/ml (= 2.4 mg/L) at 6 hours after the dose is administered. The elimination rate constant, kel, is 0.17 hr- 1) and the apparent volume of distribution, V, is 25 L.

Answer: Rearrange Equaton 5.11.1 to give Equation 5.13.1

Substituting in the values we know

CHECK the UNITS

Try your own calculation

Elimination rate constant:
Apparent Volume of Distribution: Cannot be zero
Keep Cp above:
for how long:

Cp0 is:
and the required Dose is:
If you get the Error Message Value is not a numeric literal or NaN this probably means that one of the required parameter fields is empty or a value is inappropriate.

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Copyright 2001-3 David W. A. Bourne (david@boomer.org)

This file was last modified: Monday 07 Jul 2003 at 12:08 PM