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IV Bolus - Example 4

Question: After an I.V. bolus dose of 500 mg the data collected in Table 5.14.1 were collected. Calculate kel and V.

Table 5.14.1 Concentration versus Time Data
Time (hr) 1 2 3 4 6 8 10
Cp (mcg/ml) 72 51 33 20 14 9 4

Plot the data on semi-log graph paper (Figure 5.14.1) and determine Cp1, Cp2, t1 and t2.

Figure 5.14.1 Plot of Cp Versus Time on Semi-log Graph Paper After an I.V. Bolus Dose of 500 mg.

and

Try your own calculation

IV Bolus Dose:
First concentration:
Time of first Cp value:
Second concentration:
Time of second Cp value:
 
kel is:
t1/2 is:
Cp0 is:
V is:
and Total Body Clearance is:
If you get the Error Message Value is not a numeric literal or NaN this probably means that one of the required parameter fields is empty or a value is inappropriate.
For practice you can plot these data collected after an IV bolus dose and estimate pharmacokinetic parameters. Compare your answers with the computer!

Use drug specific parameter values to estimate concentration versus time plots

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Copyright 2001-3 David W. A. Bourne (david@boomer.org)

This file was last modified: Thursday 31 Jul 2003 at 08:14 PM