Grading

General Exam Policy The student is only allowed to have a pen, pencil, eraser with them during the exam. A standard calculator (Sharp EL-501V) and ruler will be provided to each student for use in the exam. Coats, jackets, hats (including ballcaps), calculators, Palm and other PDA devices, computers, cell phones, pagers, papers, backpacks, briefcases, etc, MUST be placed at the front of the classroom prior to the exam start. Students who leave the exam room during the exam will not be allowed to re-enter the room until the last student has completed their exam.

First Semester Exam: To maintain parity between the two campuses there will be no content questions allowed during the exam. If you think there is a problem with a question you may write a short (one sentence) explanation of the problem for consideration by the grader. The exam will be returned after grading and may be reviewed in class. Any and all questions about the exam grade must be resolved within one week of your receiving the graded exam. A make-up exam may be available on request with a suitable excuse. The schedule for any make-up exam will be decided by the instructor.

Second Semester Exam: To maintain parity between the two campuses there will be no content questions allowed during the exam. If you think there is a problem with a question you may write a short (one sentence) explanation of the problem for consideration by the grader. The exam will be returned after grading and may be reviewed in class. Any and all questions about the exam grade must be resolved within one week of your receiving the graded exam. A make-up exam may be available on request with a suitable excuse. The schedule for any make-up exam will be decided by the instructor.

Homework: You may work on the homework with the help of your colleagues and/or your instructor; however, you must turn in your own effort for credit. Many of the homework exercises will be submitted on-line. You may repeat these on-line homework sets to improve your grade but this will involve redoing the exercise with new data. Homework that is turned in to the instructor will be returned after grading. Homework may be reviewed in class. Any and all questions about the homework grade must be resolved within one week of the graded homework being returned. Homework must be turned in on time for full credit.

Check or change your preferred first or last name, your location, or change your password for the class here. Check your homework scores here.

Project: The project involves the pharmacokinetic analysis of a simulated set of data. Each student will receive a different set of data and there are a number of different scenarios. The preliminary report will consist of graphs of the data on linear and semi-log paper and at least one preliminary representation of a suitable pharmacokinetic model. The preliminary report will be due approximately one month after the data is handed out. The group presentation will be an in-class progress report prepared and presented as a group. Each group will consist of students with the same scenario. These in-class presentations will be scheduled before Thanksgiving. Each member of the group will receive the same grade for group presentation. The final report will be an individual report providing a best model and weighting scheme. This report will include discussions of alternate models and weighting schemes. The most important part of this report will be your reasons or justification for your choice of the best model and weighting scheme.

You may work on the project with the help of your colleagues and/or your instructor; however, you must turn in your own effort on the reports for credit.

Final Exam: To maintain parity between the two campuses there will be no content questions allowed during the exam. If you think there is a problem with a question you may write a short (one sentence) explanation of the problem for consideration by the grader. The final exam will be retained by the instructor but will be available for review by request for two weeks. A make-up exam may be available on request with a suitable excuse. Because of end of semester scheduling this will result in an incomplete (I) grade being awarded. The incomplete will be changed to a letter grade after the completion of the course requirements.

Check your scores on the course website often to keep track of your grades.

Percent Score	Grade
100 - 90	A
89 - 80	B
79 - 70	C
69 - 60	D
Below 60	Fail

Academic Misconduct Academic Misconduct includes any act which improperly affects the evaluation of a student's academic performance or achievement. Students suspected of academic misconduct, or found to be in violation of the College Honor Code will be dealt with as per OUHSC Policy.

• Preliminary Data Analysis (Individual work) due - 29th September 2003. The preliminary report will consist of graphs of the data on linear and semi-log paper, at least one preliminary representation of a suitable pharmacokinetic model and one complete output from a run with your data using Boomer. The preliminary report must be your own work.
• Group Presentation (Group) due - During the week of November 3rd 2003 This is to be an in-class presentation of progress, approaches, pitfalls, expected outcome by one or two member of each group. Use of PowerPoint or overheads is encouraged. See me if/when you need help with Powerpoint or overheads - or the project.
  • Friday, 7th November 2003 - Group B, C2, J1, J2:
  • Monday, 10th November 2003 - Group A, D, E, K:
  • Wednesday, 12th November 2003 - Group C1, F, I1, I2:
• Final Report (Individual work) due - 1st December 2003. Submitted Report should include Title, Student Name, Data Sheet (page with problem), Brief summary, narrative description (with tables and figures as appropriate) of what was done to analyse the data and how the final analysis was derived. This should include a discussion of the final choice of model and weighting scheme. The final (ONLY) 'best fit' output from the nonlinear regression program should be included with the report. This output should include a description of the model, final parameter values with statistics, final calculated and observed data with residuals, calculated and observed versus time plots and weighted residual versus time plots. In the past final output from Boomer has been to most complete and use of Boomer for this final report is HIGHLY recommended. With other programs leaving out essential pieces to the report is common. The final report must be your own work.
• Plagiarism is the appropriation or imitation of another's ideas and manner of expressing them, as in art, literature, etc. to be passed off as one's own work The Macquarie Dictionary, Revised Edition 1985
  • If you must quote someone else quote it exactly and either indent left and right margin, use italics, or quotation marks AND provide a complete citation. Keep to a minimum
  • Ideas or information obtained from another source must be fully cited
  • Changing a few words is not sufficient. Learn from references but write your report in your own words.

• On line resources

  Windows version may be unzipped or restored with Winzip or Aladdin Systems Expander which will expand both the Macintosh and the .sit/.zip version on Windows.

  The files below are only starting points!! They are not final answers.

  • Project A
    • Boomer .BAT file - One compartment model with simultaneous fit to four lines after an IV infusion. Macintosh, UNIX, and DOS versions of the .BAT as .sit files.
  • Project B
    • Boomer .BAT file - One compartment model with simultaneous fit to data after IV and oral administration. Macintosh, UNIX, and DOS versions of the .BAT as .sit files.
  • Project C
    Three data sets collected after a 25, 100, or 400 mg IV Bolus
    • Boomer .BAT file - One compartment model with simultaneous fit to three lines. Macintosh, UNIX, and DOS versions of the .BAT as .sit files.
    • Boomer .BAT file - One compartment model with sequential fit to three lines. (in this example the t_1/2 is close to 60 hours so I gave the second dose at 336 hr and the third dose at 672 hr. Macintosh, UNIX, and DOS versions of the .BAT as .sit files.
  • Project D
    • Boomer .BAT file - One compartment model after an Multiple IV infusions. Macintosh, UNIX, and DOS versions of the .BAT as .sit files.
  • Project E
    • Boomer .BAT file - One compartment model with simultaneous fit to four lines after an IV infusion. Macintosh, UNIX, and DOS versions of the .BAT as .sit files.
  • Project F
    • Boomer .BAT file - One compartment model with simultaneous fit to data after IV and oral administration. Macintosh, UNIX, and DOS versions of the .BAT as .sit files.
  • Project G
    • Boomer .BAT file - One compartment model with multiple IV Bolus Doses. Macintosh, UNIX, and DOS versions of the .BAT as .sit files.
  • Project H
    • Boomer .BAT file - One compartment model with simultaneous fit to four lines after an IV bolus dose. Macintosh, UNIX, and DOS versions of the .BAT as .sit files.
  • Project I
    • Boomer .BAT file - One compartment model with simultaneous fit to data after IV and oral administration. Macintosh, UNIX, and DOS versions of the .BAT as .sit files.
  • Project J
    Three data sets collected after a 25, 100, or 400 mg IV Bolus
    • Boomer .BAT file - One compartment model with simultaneous fit to three lines. Macintosh, UNIX, and DOS versions of the .BAT as .sit files.
    • Boomer .BAT file - One compartment model with sequential fit to three lines. (in this example the t_1/2 is close to 60 hours so I gave the second dose at 336 hr and the third dose at 672 hr. Macintosh, UNIX, and DOS versions of the .BAT as .sit files.
  • Project K
    • Boomer .BAT file - One compartment model after an Multiple IV infusions. Macintosh, UNIX, and DOS versions of the .BAT as .sit files.
  • Project L
    • Boomer .BAT file - One compartment model with simultaneous fit to four lines after an IV bolus dose. Macintosh, UNIX, and DOS versions of the .BAT as .sit files.
  • F-Table P = 0.05
  Useful References
  • Boxenbaum, H.G., Riegelman, S., and Elashoff, R.M. Statistical Estimation in Pharmacokinetics, J. Pharmacokin. Biopharm., 2(2), 123-148 (1974)

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Copyright 2001-3 David W. A. Bourne (david@boomer.org)