** FINAL OUTPUT FROM Boomer (v2.8.3) ** 27 August 2002 --- 2:04:27 pm Title: Example 22 Page 715 Bauer, L Input: From eg22.BAT Output: To eg22.OUT Data for [Theophylline] came from keyboard (or ?.BAT) Fitting algorithm: Simplex Method Weighting for [Theophylline] by Equal weight Bayesian Fitting to data: Numerical integration method: 2) Fehlberg RKF45 with 1 de(s) With relative error .1000E-03 With absolute error .1000E-03 PC = .1000E-04 ** FINAL PARAMETER VALUES *** # Name Value S.D. C.V. % Lower <-Limit-> Upper Population mean S.D. (Weight) Weighted residual 1) V/Wt .48099 .10 5.0 .5000 .8000E-01 12.50 -.2376 2) CL/Wt .14913E-01 .0 1.0 .1450E-01 .3600E-02 277.8 .1147 AIC = 1.939 Final WSS = .3568 R-squared = .9021 Correlation Coeff = 1.000 ** FINAL OUTPUT FROM Boomer (v2.8.3) ** 27 August 2002 --- 2:04:27 pm Title: Example 22 Page 715 Bauer, L Input: From eg22.BAT Output: To eg22.OUT Data for [Theophylline] came from keyboard (or ?.BAT) Fitting algorithm: DAMPING-GAUSS/SIMPLEX Weighting for [Theophylline] by Equal weight Bayesian Fitting to data: Numerical integration method: 2) Fehlberg RKF45 with 1 de(s) With relative error .1000E-03 With absolute error .1000E-03 DT = .1000E-02 PC = .1000E-04 Loops = 1 Damping = 1 ** FINAL PARAMETER VALUES *** # Name Value S.D. C.V. % Lower <-Limit-> Upper Population mean S.D. (Weight) Weighted residual 1) V/Wt .48096 .104E-01 2.2 .10 5.0 .5000 .8000E-01 12.50 -.2381 2) CL/Wt .14915E-01 .144E-02 9.7 .0 1.0 .1450E-01 .3600E-02 277.8 .1153 AIC = 1.939 Final WSS = .3568 R-squared = .9021 Correlation Coeff = 1.0000 Model and Parameter Definition # Name Value Type From To Dep Start Stop 1) Initial Cp = .000 1 0 1 0 0 0 2) Weight = 60.00 19 0 0 0 0 0 3) V/Wt = .4810 19 0 0 0 0 0 4) V = 28.86 18 1 1 5002003 0 0 5) CL/Wt = .1491E-01 19 0 0 0 0 0 6) CL = .8949 19 0 0 5002005 0 0 7) kel = .3101E-01 2 1 0 7006004 0 0 8) Infusion s/s = .5000 0 0 0 0 0 0 9) Loading Infusion = 800.0 3 0 1 0 0 1 10) Maintenance Infusion= 40.00 3 0 1 0 1 0 Data for [Theophylline] :- DATA # Time Calculated Observed (Weight) Weighted residual 1 2.000 15.1608 15.6000 1.00000 .439201 2 6.000 18.6066 18.3000 1.00000 -.306568 WSS for data set 1 = .2869 R-squared = .9213 Correlation Coeff = 1.0000 Plots of observed (*) and calculated values (+) versus time for [Theophylline] . Superimposed points (X) 18.61 Linear 18.61 Semi-log | + | + | | | | | * | * | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | * | * | | | | | | + | + |_____________________________________ |_____________________________________ 15.16 15.16 0 <--> 6.0 0 <--> 6.0 Plot of Std Wtd Residuals (X) Plot of Std Wtd Residuals (X) versus time for [Theophylline] versus calcd Cp(i) for [Theophylline] 1.040 1.040 |X |X | | | | | | | | | | | | | | | | | | 0===================================== 0===================================== | | | | | | | | | | | X | X | | -.7258 -.7258 2.0 <--> 6.0 15. <--> 19.