Bioavailability Calculations
Student Objectives for this Chapter
- To appropriately use
- the method of Residuals
- the method of Wagner and Nelson
- the method of Inspection
to calculate ka
- To calculate F using plasma or urine data
- Understand the difference between absolute and relative bioavailability
- Fit IV and Oral Data Simultaneously
On most occasions you will be able to get the parameter values from tables and
references. However, you should also know how to get these values from the
data. The two parameters we will concentrate on are ka and F. These values can
be used to compare dosage forms or brands. In Chapter 17 we saw the effect changing ka or F has on the plasma concentration time curve. In this chapter we will calculate ka and F from drug concentration versus time data.
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Copyright 2001-3 David W. A. Bourne (david@boomer.org)
This file was last modified:
Tuesday 01 Jul 2003 at 03:47 PM