** FINAL OUTPUT FROM Boomer (v3.0.10) **      11 July 2003 ---  1:41:23 pm

 Title:  Fit to Oral and IV Data Simultaneously                      
 Input: From c1801.BAT                                                       
 Output:  To C1801.OUT                                                       
 Data for Cp-IV           came from keyboard (or ?.BAT)                                             
 Data for Cp-PO           came from keyboard (or ?.BAT)                                             
 Fitting algorithm: Simplex Method             
 Weighting for Cp-IV           by 1/Cp(Obs )^2                                      
 Weighting for Cp-PO           by 1/Cp(Obs )^2                                      
 Numerical integration method: 2) Fehlberg RKF45                          
          with  3 de(s)
 With relative error    .1000E-03
 With absolute error    .1000E-03
 PC =    .1000E-04

                    ** FINAL PARAMETER VALUES ***

  #  Name                  Value       S.D.       C.V. %  Lower <-Limit-> Upper

  1) kel-IV                 .20133                             .0       1.0    
  2) V-IV                   40.049                            1.0       .10E+04
  3) F                      .80398                            .50       1.1    
  4) ka-PO                  1.9827                             .0       10.    

 AIC =   -64.8147      Log likelihood =  -14.7     Schwartz factor =   -20.2376    
 Final WSS =    .105575E-01 R-squared =    .9993     Correlation Coeff =    .9995    

 ** FINAL OUTPUT FROM Boomer (v3.0.10) **      11 July 2003 ---  1:41:23 pm

 Title:  Fit to Oral and IV Data Simultaneously                      
 Input: From c1801.BAT                                                       
 Output:  To C1801.OUT                                                       
 Data for Cp-IV           came from keyboard (or ?.BAT)                                             
 Data for Cp-PO           came from keyboard (or ?.BAT)                                             
 Fitting algorithm: DAMPING-GAUSS/SIMPLEX      
 Weighting for Cp-IV           by 1/Cp(Obs )^2                                      
 Weighting for Cp-PO           by 1/Cp(Obs )^2                                      
 Numerical integration method: 2) Fehlberg RKF45                          
          with  3 de(s)
 With relative error    .1000E-03
 With absolute error    .1000E-03
 DT =    .1000E-02     PC =    .1000E-04 Loops =     2
 Damping =     1

                    ** FINAL PARAMETER VALUES ***

  #  Name                  Value       S.D.       C.V. %  Lower <-Limit-> Upper

  1) kel-IV                 .20130       .433E-02   2.1        .0       1.0    
  2) V-IV                   40.055       .674       1.7       1.0       .10E+04
  3) F                      .80402       .125E-01   1.6       .50       1.1    
  4) ka-PO                  1.9837       .720E-01   3.6        .0       10.    

 AIC =   -64.8150      Log likelihood =  -14.7     Schwartz factor =   -20.2376    
 Final WSS =    .105573E-01 R-squared =    .9993     Correlation Coeff =    .9995    

 Model and Parameter Definition

  #  Name                    Value       Type From To     Dep  Start Stop

  1) Dose-IV             =   100.0        1    0    1       0    0    0
  2) kel-IV              =   .2013        2    1    0       0    0    0
  3) V-IV                =   40.06       18    1    1       0    0    0
  4) F                   =   .8040       19    0    0       0    0    0
  5) Dose-PO             =   250.0       19    0    0       0    0    0
  6) F*Dose-PO           =   201.0        1    0    2 5004005    0    0
  7) ka-PO               =   1.984        2    2    3       0    0    0
  8) kel-PO              =   .2013        2    3    0 1002000    0    0
  9) V-PO                =   40.06       18    3    2 1003000    0    0

 Data for Cp-IV           :-

 DATA #   Time       Observed      Calculated    (Weight)  Weighted residual

     1     .000        .00000       2.49656        .00000        .00000    
     2    .2500       2.37000       2.37403       .421941      -.169881E-02
     3    1.000       2.10000       2.04134       .476191       .279312E-01
     4    2.000       1.70000       1.66913       .588235       .181573E-01
     5    4.000       1.03000       1.11594       .970874      -.834345E-01
     6    6.000       .785000       .746086       1.27389       .495720E-01

     WSS for data set  1 =    .1053E-01
               R-squared =    .9943     Correlation Coeff =    .9966    

 Data for Cp-PO           :-

 DATA #   Time       Observed      Calculated    (Weight)  Weighted residual

     1     .000        .00000        .00000        .00000        .00000    
     2    .2500       1.91000       1.90956       .523560       .229181E-03
     3    .5000       2.98000       2.97878       .335570       .409152E-03
     4    .7500       3.54000       3.54085       .282486      -.239025E-03
     5    1.000       3.80000       3.79839       .263158       .423507E-03
     6    1.500       3.84000       3.84444       .260417      -.115720E-02
     7    2.000       3.62000       3.62830       .276243      -.229238E-02
     8    3.000       3.04000       3.03860       .328947       .462014E-03
     9    4.000       2.49000       2.49443       .401606      -.178067E-02
    10    5.000       2.04000       2.04097       .490196      -.473915E-03
    11    6.000       1.67000       1.66901       .598802       .592406E-03
    12    7.000       1.37000       1.36471       .729927       .385812E-02

     WSS for data set  2 =    .2590E-04
               R-squared =   1.0000     Correlation Coeff =   1.0000    

 Maximum value for Cp-IV           is      2.3700     at       .2500    

 Calculation of AUC and AUMC based on trapezoidal rule

 AUC and AUMC for Cp-IV           using Observed data

       Time         Concentration      AUC             AUMC

       .00000          .00000    
      .250000         2.37000         .608320         .740625E-01
      1.00000         2.10000         2.28457         1.08375    
      2.00000         1.70000         4.18457         3.83375    
      4.00000         1.03000         6.91457         11.3538    
      6.00000         .785000         8.72957         20.1838    
                                      12.6291         62.9526    

 Secondary Parameters

MRT =      4.9847    

 Half-life values for each first order rate constant

   Parameter   2 has a half-life of kel-IV is       3.44    
   Parameter   7 has a half-life of ka-PO is       .349    
   Parameter   8 has a half-life of kel-PO is       3.44    

 Dose/AUC (= Clearance/F)

   Parameter   1 gives Dose-IV/AUC (CL/F) of       7.92    
   Parameter   6 gives F*Dose-PO/AUC (CL/F) of       15.9    

 Calculation of AUC and AUMC using Method 9 of R.D. Purves

 AUC and AUMC for Cp-IV           using Observed data

       Time         Concentration      AUC             AUMC

       .00000          .00000    
      .250000         2.37000    
      1.00000         2.10000         2.69000         1.52000    
      2.00000         1.70000         4.58296         4.32613    
      4.00000         1.03000         7.25724         12.1266    
      6.00000         .785000         9.06116         21.0646    
                                      12.9607         63.8334    

 Secondary Parameters

MRT =      4.9251    

 Half-life values for each first order rate constant

   Parameter   2 has a half-life of kel-IV is       3.44    
   Parameter   7 has a half-life of ka-PO is       .349    
   Parameter   8 has a half-life of kel-PO is       3.44    

 Dose/AUC (= Clearance/F)

   Parameter   1 gives Dose-IV/AUC (CL/F) of       7.72    
   Parameter   6 gives F*Dose-PO/AUC (CL/F) of       15.5    


 Maximum value for Cp-PO           is      3.8400     at       1.500    

 Calculation of AUC and AUMC based on trapezoidal rule

 AUC and AUMC for Cp-PO           using Observed data

       Time         Concentration      AUC             AUMC

       .00000          .00000    
      .250000         1.91000         .238750         .596875E-01
      .500000         2.98000         .850000         .305625    
      .750000         3.54000         1.66500         .823750    
      1.00000         3.80000         2.58250         1.63063    
      1.50000         3.84000         4.49250         4.02063    
      2.00000         3.62000         6.35750         7.27063    
      3.00000         3.04000         9.68750         15.4506    
      4.00000         2.49000         12.4525         24.9906    
      5.00000         2.04000         14.7175         35.0706    
      6.00000         1.67000         16.5725         45.1806    
      7.00000         1.37000         18.0925         54.9856    
                                      24.8987         136.443    

 Secondary Parameters

MRT =      5.4799    

 Half-life values for each first order rate constant

   Parameter   2 has a half-life of kel-IV is       3.44    
   Parameter   7 has a half-life of ka-PO is       .349    
   Parameter   8 has a half-life of kel-PO is       3.44    

 Dose/AUC (= Clearance/F)

   Parameter   1 gives Dose-IV/AUC (CL/F) of       4.02    
   Parameter   6 gives F*Dose-PO/AUC (CL/F) of       8.07    

 Calculation of AUC and AUMC using Method 9 of R.D. Purves

 AUC and AUMC for Cp-PO           using Observed data

       Time         Concentration      AUC             AUMC

       .00000          .00000    
      .250000         1.91000    
      .500000         2.98000         .885000         .283333    
      .750000         3.54000         1.71292         .803698    
      1.00000         3.80000         2.64000         1.61625    
      1.50000         3.84000         4.60167         4.06917    
      2.00000         3.62000         6.49792         7.38302    
      3.00000         3.04000         9.96069         15.9916    
      4.00000         2.49000         12.7908         25.8513    
      5.00000         2.04000         15.0916         36.1672    
      6.00000         1.67000         16.9682         46.4577    
      7.00000         1.37000         18.5020         56.4022    
                                      25.3082         137.860    

 Secondary Parameters

MRT =      5.4472    

 Half-life values for each first order rate constant

   Parameter   2 has a half-life of kel-IV is       3.44    
   Parameter   7 has a half-life of ka-PO is       .349    
   Parameter   8 has a half-life of kel-PO is       3.44    

 Dose/AUC (= Clearance/F)

   Parameter   1 gives Dose-IV/AUC (CL/F) of       3.95    
   Parameter   6 gives F*Dose-PO/AUC (CL/F) of       7.94    

Plots of observed (*) and calculated values (+)
           versus time for Cp-IV          . Superimposed points (X)

    2.497      Linear                      2.497      Semi-log
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 |_____________________________________  |*____________________________________
     .000                                  .7461    
 0              <-->             6.0     0              <-->             6.0    
 Plot of Std Wtd Residuals (X)         Plot of Std Wtd  Residuals (X)
   versus time for Cp-IV                 versus log(calc Cp(i)) for Cp-IV          

    1.805                                  1.805    
 |                                    X  |X                                    
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 0X====================================  0====================================X
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   -3.038                                 -3.038    
       .0       <-->             6.0          .75       <-->             2.5    
Plots of observed (*) and calculated values (+)
           versus time for Cp-PO          . Superimposed points (X)

    3.844      Linear                      3.844      Semi-log
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     .000                                  1.365    
 0              <-->             7.0     0              <-->             7.0    
 Plot of Std Wtd Residuals (X)         Plot of Std Wtd  Residuals (X)
   versus time for Cp-PO                 versus log(calc Cp(i)) for Cp-PO          

    .1405                                  .1405    
 |                                    X  |X                                    
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 0X==X=================================  0=================================X===
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   -.8348E-01                             -.8348E-01
       .0       <-->             7.0          1.4       <-->             3.8    
 Plot of Std Wtd Residuals (X)        Plot of Std Wtd  Residuals (X)
   versus time for all data              versus log(calc Cp(i)) for all data       

    1.805                                  1.805    
 |                              X        |X                                    
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 |     X                                 |                      X              
 |          X                            |                 X                   
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 0XXXX=X=========X==============X=====X  0=============X===X==X=====X===X===XX=
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   -3.038                                 -3.038    
       .0       <-->             7.0          .75       <-->             3.8