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Suspension Dosage Forms
A well formulated suspension is second only to a solution in terms
of superior bioavailability. Absorption may well be dissolution
limited, however a suspension of a finely divided powder will
maximize the potential for rapid dissolution. A good correlation can
be seen for particle size and absorption rate. With very fine
particle sizes the dispersibility of the powder becomes important.
The addition of a surface active agent will improve dispersion of a
suspension and may improve the absorption of very fine particle size
suspensions otherwise caking may be a problem. As a suspension ages there is potential for increased particle size with an accompanying decrease in dissolution rate. Smaller particles have higher solubility and will tend is disappear with the drug coming out of solution on larger particles.
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Copyright 2001-3 David W. A. Bourne (david@boomer.org)
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