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Capsule Dosage Forms
In theory a capsule dosage form should be quite efficient. The
hard gelatin shell should disrupt rapidly and allow the contents to
be mixed with the G-I tract contents. The capsule contents should not
be subjected to high compression forces which would tend to reduce
the effective surface area, thus a capsule should perform better than
a tablet. This is not always the case. If a drug is hydrophobic a
dispersing agent should be added to the capsule formulation. These
diluents will work to disperse the powder, minimize aggregation and
maximize the surface area of the powder. Tightly packed capsules may have reduced dissolution and bioavailability.
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Copyright 2001-3 David W. A. Bourne (david@boomer.org)
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