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Multiple Oral Dose Administration

Student Objectives for this Chapter

To recognize and use the integrated equations for multiple oral dose administration
To calculate appropriate multiple dose regimen
To define, calculate and use the parameter
To use the superposition principle to calculate Cp after non uniform dosing regimen

So far we have looked at multiple IV bolus administration. In an analogous fashion, equations can be developed which enable you to calculate the plasma concentration achieved following multiple oral administration. To start the plasma concentration achieved following a single oral dose can be given by:

Equation 26.1.1 Cp after a Single Oral Dose

This can be converted to an equation describing plasma concentration at any time following n equal doses with constant dosing interval t using a "multiple dose function".

Equation 26.1.2 Multiple Dose Function

Equation 26.1.3 Cp after a Single Oral Dose - Uniform Dose and Interval, τ
General Equation

Figure 26.1.1 Plot of Cp Versus Time for Multiple Oral Doses showing Cp_max and Cp_min

Click on the figure to view the Java Applet window
Java Applet as a Semi-log Plot

The plasma concentration versus time curve described by this equation is similar to the IV curve in that there is accumulation of the drug in the body to some plateau level and the plasma concentrations fluctuate between a minimum and a maximum value.

The Cpmax value could be calculated at the time t = t_peak after many doses (n -> ∞) but it is complicated by the need to determine the value for t_peak.

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