PHAR 7632/7633 Syllabus

Topics to be Covered in PHAR 7632 and PHAR 7633

Glossary

PHAR 7632

• 1. Introduction (PHAR 7632)
• 2. Mathematical material
• 3. Pharmaceutical analysis
• 4. Pharmacokinetics introduction
• 5. One compartment IV bolus
• 6. Modeling
• 7. More Laplace transforms
  • More about the Laplace Transform Method
  • Finger Print Method, Inverse Laplace Transform
  • Finger Print Method - Example 1
  • Finger Print Method - Example 2
  • Multi Compartment Pharmacokinetic Models
  • Finger Print Method - Example 3
  • Convolution

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    Textbook pp 44-48
    References
    • Mayersohn, M. and Gibaldi, M 1971 "Mathematical Methods in Pharmacokinetics. II. "Solution of the Two Compartment Open Model," Amer. J. Pharm. Ed., 35:19-28
    • Benet, L.Z. and Turi, J.S. 1971 "Use of the General Partial Fraction Theorem for Obtaining Inverse Laplace Transforms in Pharmacokinetic Analysis," J. Pharm. Sci., 60:1593-1594
    • Benet, L.Z. 1972 "General Treatment of Linear Mammillary Models with Elimination from any Compartment as Used in Pharmacokinetics," J. Pharm. Sci., 61:536-541
• 8. Program set-up
• 9. Program output evaluation
• 12. Analysis of urine data
• 15. Intravenous infusion
• 16. Routes of drug administration
• 17. Pharmacokinetics of oral administration
• 21. Bioavailability studies

  PHAR 7633

• 14. Introduction (PHAR 7633)
• 10. Numerical integration
• 11. Optimization
• 13. Weighting schemes
• 18. Bioavailability calculations
• 19. Selection of the "best" model
• 20. Identifiability
• 22. Physiological factors affecting oral absorption
• 23. Physical-Chemical factors affecting oral absorption
• 24. Formulation factors affecting oral absorption
• 25. Multiple IV bolus dose administration
• 26. Multiple oral dose administration
• 27. Routes of excretion
• 28. Drug metabolism
• 29. Drug distribution
• 30. Multi-compartmental pharmacokinetic models
• 31. Non-linear pharmacokinetic models
• 32. Clinical applications of pharmacokinetics
• 33. Optimal sampling
• 34. Bayesian analysis and population modeling
• 35. Pharmacodynamic models
• 36. Physiologically based pharmacokinetic models

• Textbook == Mathematical Modeling of Pharmacokinetic Data by David W.A. Bourne
• Boomer == Boomer On-line Manual
• Booklet == Pieper, J.A. and Rutledge, D.R. 1989 Current Concepts - Laboratory Techniques for Pharmacists, Upjohn, Kalamazoo, MI (Upjohn Publication #8804-03 June 1989) (On reserve in the Bird Library)
• (*) Links to relevant or similar material from PHAR 4634 Online

Copyright 2001-3 David W. A. Bourne (david@boomer.org)