PHAR 7632/7633 Syllabus

Topics to be Covered in PHAR 7632 and PHAR 7633

Glossary

PHAR 7632

• 1. Introduction (PHAR 7632)
• 2. Mathematical material
• 3. Pharmaceutical analysis
• 4. Pharmacokinetics introduction
• 5. One compartment IV bolus
• 6. Modeling
• 7. More Laplace transforms
• 8. Program set-up
• 9. Program output evaluation
• 12. Analysis of urine data
• 15. Intravenous infusion
  • One Compartment Linear Model
  • Continuous IV Infusion - Steady State
  • Continuous IV Infusion - Time to Reach Steady State
  • Combined Infusion and bolus administration
  • Combined Slow and Fast Infusion
  • Post Infusion

    ---

  • Slide images for the exercises from the book by Larry A. Bauer, Applied Clinical Pharmacokinetics. Example 4 and Example 22
    
  • Boomer .BAT files for example 22
  • Boomer .OUT files for example 22

    ---

    For practice
    Try calculating concentrations or required infusion rates during an IV infusion.
    Try calculating doses and parameters during the post IV infusion period.
    Try estimating parameter values from a series of post-infusion data

    ---

  • Slides in PDF Format
• 16. Routes of drug administration
• 17. Pharmacokinetics of oral administration
• 21. Bioavailability studies

  PHAR 7633

• 14. Introduction (PHAR 7633)
• 10. Numerical integration
• 11. Optimization
• 13. Weighting schemes
• 18. Bioavailability calculations
• 19. Selection of the "best" model
• 20. Identifiability
• 22. Physiological factors affecting oral absorption
• 23. Physical-Chemical factors affecting oral absorption
• 24. Formulation factors affecting oral absorption
• 25. Multiple IV bolus dose administration
• 26. Multiple oral dose administration
• 27. Routes of excretion
• 28. Drug metabolism
• 29. Drug distribution
• 30. Multi-compartmental pharmacokinetic models
• 31. Non-linear pharmacokinetic models
• 32. Clinical applications of pharmacokinetics
• 33. Optimal sampling
• 34. Bayesian analysis and population modeling
• 35. Pharmacodynamic models
• 36. Physiologically based pharmacokinetic models

Copyright 2001-3 David W. A. Bourne (david@boomer.org)