PHAR 7632/7633 Syllabus

Topics to be Covered in PHAR 7632 and PHAR 7633

Glossary

PHAR 7632

• 1. Introduction (PHAR 7632)
• 2. Mathematical material
• 3. Pharmaceutical analysis
• 4. Pharmacokinetics introduction
• 5. One compartment IV bolus
• 6. Modeling
• 7. More Laplace transforms
• 8. Program set-up
• 9. Program output evaluation
• 12. Analysis of urine data
• 15. Intravenous infusion
• 16. Routes of drug administration
• 17. Pharmacokinetics of oral administration
• 21. Bioavailability studies

  PHAR 7633

• 14. Introduction (PHAR 7633)
• 10. Numerical integration
• 11. Optimization
• 13. Weighting schemes
• 18. Bioavailability calculations
  • Bioavailability Calculations
  • Method of Residuals
  • Wagner-Nelson Method
  • Method of Inspection
  • Calculation of F
  • Non-Linear Regression Analysis

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  • Practice problems illustrating the method of residuals for estimating ka
  • Practice problems illustrating the Wagner-Nelson Method for estimating ka
  • Practice calculating the bioavailability parameter, F

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  • Bioavailability calculations - PHAR 4634 pages
  • Slides in PDF Format
• 19. Selection of the "best" model
• 20. Identifiability
• 22. Physiological factors affecting oral absorption
• 23. Physical-Chemical factors affecting oral absorption
• 24. Formulation factors affecting oral absorption
• 25. Multiple IV bolus dose administration
• 26. Multiple oral dose administration
• 27. Routes of excretion
• 28. Drug metabolism
• 29. Drug distribution
• 30. Multi-compartmental pharmacokinetic models
• Non-linear pharmacokinetic models
• Clinical applications of pharmacokinetics
• Optimal sampling
• Bayesian analysis and population modeling
• Pharmacodynamic models
• Physiologically based pharmacokinetic models

Copyright 2001-3 David W. A. Bourne (david@boomer.org)