PHAR 7633 Chapter 3

Biopharmaceutics and Pharmacokinetic Introduction

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Disposition (DME: Distribution, Metabolism, Excretion)

In a Family circle cartoon a young patient might asks "How does the medicine know where to go". Drug moves throughout the body directed by the physicochemical properties of the drug and the physiology of the body. Once the drug is absorbed what happens to it? The processes of excretion, metabolism, and distribution take over to move the drug through and out of the body. Drug is distributed throughout the body depending on the physicochemical properties of the drug and the physiological properties of the body membranes and fluids. The chemistry of the compound and the enzymes available determine the metabolism of the drug. The molecular size, polarity and binding influence the drug excretion.

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