PHAR 7633 Chapter 4

One Compartment IV Bolus

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IV Bolus One Compartment Model

Student Objectives for this Chapter

After completing the material in this chapter each student should:- Definition: Pharmacokinetics is the study of drug and/or metabolite kinetics in the body. It deals with a mathematical description of the rates of drug movement into, within and exit from the body. It also includes the study of drug metabolism or biotransformation rates. The body is a very complex system and a drug undergoes many steps as it is being absorbed, distributed through the body, metabolized or excreted (ADME).

One compartment Scheme

Figure 5.1.1 Drug Disposition

The drug also interacts with receptors and causes therapeutic and/or toxic responses. Although the details of drug kinetics are complicated it is fortunate that we can often approximate drug kinetic processes using "simple" mathematical models.


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