PHAR 7633 Chapter 14

Multiple IV Bolus Dose Administration

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Multiple IV Bolus Dose Administration

Student Objectives for this Chapter

After completing the material in this chapter each student should:-

understand and be able to describe drug accumulation after repeated dose administration
be able to use the integrated equations for drug concentration after multiple IV bolus doses
be able to calculate suitable dosing regimens including loading dose, maintenance dose, and dosing interval
be able to define, use, and calculate the parameters:
- dosing interval, τ
- fraction remaining at the end of the dosing interval, R (= e^-kel*Τ)
- accumulation factor, 1/(1-R)
- maximum plasma concentration, Cp_max
- minimum plasma concentration, Cp_min
be able to calculate suitable multiple dose regimen to achieve desired Cp_min and Cp_max values

This Chapter will consider drug pharmacokinetics after multiple IV bolus dose administration. But, first a review of the equations for a single dose administration.

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