PHAR 7632 Chapter 15

Multiple Oral Dose Administration

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Multiple Oral Dose Administration

So far we have looked at multiple IV bolus dose administration. In an analogous fashion, equations can be developed which enable you to calculate the plasma concentration achieved following multiple oral administration. To start, the plasma concentration achieved following a single oral dose can be given by:

Equation 15.2.1 Cp after a Single Oral Dose

This can be converted to an equation describing plasma concentration at any time following n equal doses with constant dosing interval t using a "multiple dose function".

Equation 15.2.2 Multiple Dose Function

Equation 15.2.3 Cp after a Single Oral Dose - Uniform Dose and Interval, τ
General Equation

Figure 15.2.1 Plot of Cp versus Time for Multiple Oral Doses showing Cp_max and Cp_min

Click on the figure to view the Java Applet window
Java Applet as a Semi-log Plot

The plasma concentration versus time curve described by this equation is similar to the IV curve in that there is accumulation of the drug in the body to some plateau level and the plasma concentrations fluctuate between a minimum and a maximum value.

The Cpmax value could be calculated at the time t = t_peak after many doses (as n approaches ∞) but it is complicated by the need to determine the value for t_peak.

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