# Chapter 4 - Page 10 - Java 1

## Diagram Illustrating the Relationship between Clearance, Volume and Half-life

Explore the relationship between extraction ratio, blood flow, clearance, volume and elimination half-life. The hepatic (E(H)) and renal (E(R)) extration ratios may be varied between 0 and 100%. The apparent volume of distribution for different drugs may vary from a low of about 10 L up to 1000 L or more. The interrelationship between these parameters influence the overall elimination of a drug.

The derivation of these relationships include extraction ratio, clearance, elimination rate constant and half-life.

**Equation 4.3.1 Hepatic Extration Ratio**

**Equation 4.3.2 Renal Extration Ratio**

**Equation 4.3.3 Hepatic Clearance**

**Equation 4.3.4 Renal Clearance**

**Equation 4.3.5 Total Body Clearance**

**Equation 4.3.6 Elimination Rate Constant**

**Equation 4.3.7 Elimination Half-life**

Adjust the Extraction Ratio(s) and apparent Volume of Distribution to explore these relationships.

This page (http://www.boomer.org/c/p4/ja/Fig0403/Fig0403.html) was last modified:
Wednesday 26 May 2010 at 09:08 AM

Material on this website should be used for Educational or Self-Study Purposes Only

Copyright © 2001-2015 David W. A. Bourne (david@boomer.org)