Chapter 8 - Problem 1

Linear Plot of Cp versus Time after Oral Administration

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Consider a drug with the parameter values in healthy subjects: F = 0.1; V = 725 L; kel = 0.105 hr^-1; ka = 3.0 hr^-1; CL = 76 L/hr. Plot a concentration versus time curve after an oral dose of 100 mg. Contrast this with the results obtained with the same dose given to a patient with severe cirrhosis. Use the parameter values: F = 1.0; V = 675 L; kel = 0.078 hr^-1; ka = 3.0 hr^-1; CL = 54 L/hr. Pentikainen et al., 1978 Add a second line with these parameter values using the Add Line button.

	Healthy Subject	Severe Cirrhosis
F	0.1	1.0
ka (hr^-1)	3.0	3.0
kel (hr^-1)	0.105	0.078
V (L)	725	675

References

Pentikainen, P.J., Neuvonen, P.J., Torpila, S. and Syvalahti, E. 1978 Effect of Cirrhosis of the Liver on the Pharmacokinetics of Chlormethiazole, Br. Med. J., 2, 861-3 through Benet, L.Z., Massoud, N., and Gambertoglio, J.G. 1984. Pharmacokinetic Basis for Drug Treatment, Raven Press