Chapter 8 - Problem 2

Linear Plot of Cp versus Time after Oral Administration

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Consider a drug with the parameter values in healthy subjects: F = 0.30; V = 290 L; kel = 0.173 hr^-1; ka = 3.0 hr^-1; CL = 860 ml/min. Plot a concentration versus time curve after an oral dose of 80 mg. Contrast this with the results obtained with the same dose given to a patient with severe cirrhosis. Use the parameter values: F = 0.42; V = 380 L; kel = 0.063 hr^-1; ka = 3.0 hr^-1; CL = 580 ml/min. Wood et al., 1978. Add a second line with these parameter values using the Add Line button.

	Healthy Subject	Severe Cirrhosis
F	0.3	0.42
ka (hr^-1)	3.0	3.0
kel (hr^-1)	0.173	0.063
V (L)	290	380

References

Wood, A.J.J., Kornhauser, D.M., Wilkinson, G.R., Shand, D.G. and Branch, R.A. 1978 The influence of cirrhosis on steady-state blood concentrations of unbound propranolol after oral administration, Clin. Pharmacokin., 3, 478-487 through Benet, L.Z., Massoud, N., and Gambertoglio, J.G. 1984. Pharmacokinetic Basis for Drug Treatment, Raven Press