Chapter 8 - Problem 3

Linear Plot of Cp versus Time after Oral Administration

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Consider a drug with the parameter values in original product: F = 0.30; V = 180 L; kel = 0.023 hr^-1; ka = 5.0 hr^-1; CL = 69 ml/min. Plot a concentration versus time curve after an oral dose of 500 mcg (0.5 mg). Contrast this with the results obtained with the same dose but with the new formulation. Use the parameter values: F = 0.75; V = 180 L; kel = 0.023 hr^-1; ka = 5.0 hr^-1; CL = 69 ml/min. Danon et al., 1977. Add a second line with these parameter values using the Add Line button.

	Original Product	New Formulation
F	0.3	0.75
ka (hr^-1)	5.0	5.0
kel (hr^-1)	0.023	0.023
V (L)	180	180

References

Danon, A., et al. 1977 An outbreak of digoxin intoxication, Clin. Pharmacol. Ther., 21, 643 through Gibaldi, M. 1984 Biopharmaceutics and Clinical Pharmacokinetics, 3rd ed., Lea & Febiger