Multiple Oral Doses

Linear Plot of Cp versus time

Interactive graph requirements
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Changing the dosing interval and the dose in the same proportion should produce the same Cp_average concentration. However, the Cp_min and Cp_max can vary considerably.

With F = 1.0, V = 30 liter, t_1/2 = 6 hours or kel = 0.693/6 = 0.116 hr^-1, a dose of 600 mg given every 12 hours will achieve an average plasma concentration of approximately 15 mg/L. Try simulating this regimen and also the alternate regimen of 1200 mg very 24 hours and 300 mg every 6 hours. Which regimen gives the least variation between Cp_max and Cp_min?

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