Generate Cp versus Time Data for AUC calculation

IV Bolus - Linear One Compartment

A dose of 300 mg was administered to healthy volunteer. Seven blood samples were collected at 0.5, 1, 2, 4, 6, 8, 10 hours. Plasma was separated from each blood sample and analyzed for drug concentration. The collected data are shown in the table below.

Time (hr) Cp (mg/L) Δ (AUC mg.hr/L) AUC (mg.hr/L)

0

0.5
13

1
12.78

2
11.22

4
8.52

6
6.26

8
4.91

10
3.55

∞

60609068

The table above provides a set of data for you to analyze. Use these data with the trapeziodal rule shown in this equation to calculate each AUC segment:

Don't forget the first and last segments. You will need to extrapolate the concentration back to the intercept for the first segment. You will also need kel to calculate the last segment:

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Last update: Wed 31 Dec 1969 06:00:00 pm

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Time (hr)	Cp (mg/L)	Δ (AUC mg.hr/L)	AUC (mg.hr/L)
0
0.5	13
1	12.78
2	11.22
4	8.52
6	6.26
8	4.91
10	3.55
∞