Dosing Calculations

IV Bolus - Linear One Compartment Model

First, the Drug

Drug Name
Minimum Effective Drug Concentration (MEC)	mg/L
Maximum Tolerated Drug Concentration (MTC)	mg/L
Does the Apparent Volume of Distribution depend on the Patient's Weight?			L/kg
			L
Enter the drug elimination rate constant, kel,	hr-1
or the drug half-life, t1/2,	hr
or the drug total body clearance, Cl,	L/hr
or the drug total body clearance in L/hr/kg	L/hr/kg
or the drug total body clearance in ml/min	ml/min

The Patient

Enter the patient's weight if the apparent volume of distribution depends on their weight	pound
	kilogram

and finally the Dosage Form

Dose administered as a rapid IV Bolus		mg (labelled dose)
Is the chemical form in the dose different from the measured drug concentration in plasma			Molecular weight of measured drug Molecular weight of drug in dosage form
			No entry needed

The Equations

where

,

Volume, V, is V or if calculated from the patient's weight ,

The elimination rate constant, kel, is given or can be calculated from the half-life, t_1/2, as , or from the total body clearance, Cl,

Practice problem answers may not be available on occasion. These practice problems may be used for graded homework from time to time. For any given problem set this will probably be for one or two weeks at most. Please try later.