Timehr |
Cpmg/L |
ΔAUCmg.hr/L |
AUCmg.hr/L |
Cp • tmg.hr/L |
ΔAUMCmg.hr ^{2}/L |
AUMCmg.hr ^{2}/L |

0 | 1.03 | 0 | 0 | 0 | 0 | 0 |

0.25 | 0.671 | 0.213 | 0.213 | 0.168 | 0.021 | 0.021 |

0.5 | 0.501 | 0.147 | 0.359 | 0.251 | 0.0523 | 0.0733 |

0.75 | 0.417 | 0.115 | 0.474 | 0.313 | 0.0704 | 0.144 |

1 | 0.37 | A | C | 0.37 | 0.0853 | 0.229 |

1.25 | 0.341 | B | 0.661 | 0.426 | 0.0995 | 0.329 |

1.5 | 0.319 | 0.0825 | 0.744 | 0.479 | D | F |

2 | 0.286 | 0.151 | 0.895 | 0.572 | E | 0.704 |

4 | 0.193 | 0.479 | 1.37 | 0.772 | 1.34 | 2.05 |

6 | 0.13 | 0.323 | 1.7 | 0.78 | 1.55 | 3.6 |

9 | 0.0724 | 0.304 | 2 | 0.652 | 2.15 | 5.75 |

12 | 0.0402 | 0.169 | 2.17 | 0.482 | 1.7 | 7.45 |

24 | 0.00383 | 0.264 | 2.43 | 0.0919 | 3.45 | 10.9 |

Infinity | 0 | G | H | 0 | I | J |

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**Equation 30.4.1 AUC for the segment from i-1 to i**

**Equation 30.4.2 AUC for the last segment from t _{last} to infinity**

where k' is the slowest rate constant. k' can be calculated from the terminal slope of Cp versus time on semi-log graph paper.

**Equation 30.4.3 AUMC for the last segment from t _{last} to infinity**

where k' is the slowest rate constant. k' can be calculated from the terminal slope of **Cp versus time** on semi-log graph paper.

**Equation 30.4.4 Mean Resident Time (MRT)**

**Equation 30.4.5 Clearance (CL)**

**Equation 30.4.6 Steady State Apparent Volume of Distribution, V _{ss}**

Last update: Thu 19 Jan 2012 09:10:00 am