Non compartment Analysis IV Administration

A drug follows first order (i.e. linear) pharmacokinetics. A 75 mg dose was given by rapid IV administration to a patient and a number of plasma drug concentration were determined. The results are shown in the table below. A non compartmental analysis was completed and AUC and AUMC values calculated. As you can see some of these values are missing from the table. Complete the table and estimate MRT, CL, and Vss from these data.

Time
hr
Cp
mg/L
ΔAUC
mg.hr/L
AUC
mg.hr/L
Cp • t
mg.hr/L
ΔAUMC
mg.hr2/L
AUMC
mg.hr2/L
00.92400000
0.250.5330.1820.1820.1330.01670.0167
0.50.3410.1090.2910.1710.0380.0546
0.750.2460.07340.3650.1850.04440.099
10.198AC0.1980.04780.147
1.250.173B0.4670.2160.05180.199
1.50.1590.04150.5080.239DF
20.1450.0760.5840.29E0.388
40.120.2650.8490.480.771.16
60.10.221.070.61.082.24
90.07650.2651.330.6891.934.17
120.05850.2031.540.7022.096.26
240.02010.4722.010.4827.1113.4
Infinity0GH0IJ


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Some Equations:

delta AUC

Equation 30.4.1 AUC for the segment from i-1 to i


Equation 30.4.2 AUC for the last segment from tlast to infinity

where k' is the slowest rate constant. k' can be calculated from the terminal slope of Cp versus time on semi-log graph paper.


Equation 30.4.3 AUMC for the last segment from tlast to infinity

where k' is the slowest rate constant. k' can be calculated from the terminal slope of Cp versus time on semi-log graph paper.


MRT

Equation 30.4.4 Mean Resident Time (MRT)


Clearance

Equation 30.4.5 Clearance (CL)


Steady state volume

Equation 30.4.6 Steady State Apparent Volume of Distribution, Vss


Last update: Thu 19 Jan 2012 09:10:00 am
Copyright © 2002-14 David Bourne (david@boomer.org)