Timehr |
Cpmg/L |
ΔAUCmg.hr/L |
AUCmg.hr/L |
Cp • tmg.hr/L |
ΔAUMCmg.hr ^{2}/L |
AUMCmg.hr ^{2}/L |

0 | 0.913 | 0 | 0 | 0 | 0 | 0 |

0.25 | 0.74 | 0.207 | 0.207 | 0.185 | 0.0231 | 0.0231 |

0.5 | 0.651 | 0.174 | 0.381 | 0.326 | 0.0638 | 0.0869 |

0.75 | 0.6 | 0.156 | 0.537 | 0.45 | 0.0969 | 0.184 |

1 | 0.569 | A | C | 0.569 | 0.127 | 0.311 |

1.25 | 0.546 | B | 0.822 | 0.683 | 0.156 | 0.468 |

1.5 | 0.528 | 0.134 | 0.957 | 0.792 | D | F |

2 | 0.498 | 0.257 | 1.21 | 0.996 | E | 1.1 |

4 | 0.4 | 0.898 | 2.11 | 1.6 | 2.6 | 3.7 |

6 | 0.321 | 0.721 | 2.83 | 1.93 | 3.53 | 7.22 |

9 | 0.232 | 0.83 | 3.66 | 2.09 | 6.02 | 13.2 |

12 | 0.167 | 0.599 | 4.26 | 2 | 6.14 | 19.4 |

24 | 0.0451 | 1.27 | 5.53 | 1.08 | 18.5 | 37.9 |

Infinity | 0 | G | H | 0 | I | J |

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**Equation 30.4.1 AUC for the segment from i-1 to i**

**Equation 30.4.2 AUC for the last segment from t _{last} to infinity**

where k' is the slowest rate constant. k' can be calculated from the terminal slope of Cp versus time on semi-log graph paper.

**Equation 30.4.3 AUMC for the last segment from t _{last} to infinity**

where k' is the slowest rate constant. k' can be calculated from the terminal slope of **Cp versus time** on semi-log graph paper.

**Equation 30.4.4 Mean Resident Time (MRT)**

**Equation 30.4.5 Clearance (CL)**

**Equation 30.4.6 Steady State Apparent Volume of Distribution, V _{ss}**

Last update: Thu 19 Jan 2012 09:10:00 am