Timehr |
Cpmg/L |
ΔAUCmg.hr/L |
AUCmg.hr/L |
Cp • tmg.hr/L |
ΔAUMCmg.hr ^{2}/L |
AUMCmg.hr ^{2}/L |

0 | 27.6 | 0 | 0 | 0 | 0 | 0 |

0.25 | 18.9 | 5.81 | 5.81 | 4.73 | 0.591 | 0.591 |

0.5 | 15.2 | 4.26 | 10.1 | 7.6 | 1.54 | 2.13 |

0.75 | 13.4 | 3.58 | 13.7 | 10.1 | 2.21 | 4.34 |

1 | 12.5 | A | C | 12.5 | 2.82 | 7.16 |

1.25 | 11.9 | B | 19.9 | 14.9 | 3.42 | 10.6 |

1.5 | 11.5 | 2.93 | 22.9 | 17.3 | D | F |

2 | 10.8 | 5.58 | 28.4 | 21.6 | E | 24.3 |

4 | 8.66 | 19.5 | 47.9 | 34.6 | 56.2 | 80.5 |

6 | 6.92 | 15.6 | 63.5 | 41.5 | 76.2 | 157 |

9 | 4.95 | 17.8 | 81.3 | 44.6 | 129 | 286 |

12 | 3.54 | 12.7 | 94 | 42.5 | 131 | 416 |

24 | 0.924 | 26.8 | 121 | 22.2 | 388 | 804 |

Infinity | 0 | G | H | 0 | I | J |

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**Equation 30.4.1 AUC for the segment from i-1 to i**

**Equation 30.4.2 AUC for the last segment from t _{last} to infinity**

where k' is the slowest rate constant. k' can be calculated from the terminal slope of Cp versus time on semi-log graph paper.

**Equation 30.4.3 AUMC for the last segment from t _{last} to infinity**

where k' is the slowest rate constant. k' can be calculated from the terminal slope of **Cp versus time** on semi-log graph paper.

**Equation 30.4.4 Mean Resident Time (MRT)**

**Equation 30.4.5 Clearance (CL)**

**Equation 30.4.6 Steady State Apparent Volume of Distribution, V _{ss}**

Last update: Thu 19 Jan 2012 09:10:00 am