Timehr |
Cpmg/L |
ΔAUCmg.hr/L |
AUCmg.hr/L |
Cp • tmg.hr/L |
ΔAUMCmg.hr ^{2}/L |
AUMCmg.hr ^{2}/L |

0 | 14.8 | 0 | 0 | 0 | 0 | 0 |

0.25 | 12 | 3.35 | 3.35 | 3 | 0.375 | 0.375 |

0.5 | 10.6 | 2.83 | 6.18 | 5.3 | 1.04 | 1.41 |

0.75 | 9.82 | 2.55 | 8.73 | 7.37 | 1.58 | 3 |

1 | 9.38 | A | C | 9.38 | 2.09 | 5.09 |

1.25 | 9.09 | B | 13.4 | 11.4 | 2.59 | 7.68 |

1.5 | 8.87 | 2.25 | 15.7 | 13.3 | D | F |

2 | 8.53 | 4.35 | 20 | 17.1 | E | 18.4 |

4 | 7.45 | 16 | 36 | 29.8 | 46.9 | 65.2 |

6 | 6.52 | 14 | 50 | 39.1 | 68.9 | 134 |

9 | 5.34 | 17.8 | 67.8 | 48.1 | 131 | 265 |

12 | 4.37 | 14.6 | 82.3 | 52.4 | 151 | 416 |

24 | 1.96 | 38 | 120 | 47 | 597 | 1010 |

Infinity | 0 | G | H | 0 | I | J |

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**Equation 30.4.1 AUC for the segment from i-1 to i**

**Equation 30.4.2 AUC for the last segment from t _{last} to infinity**

where k' is the slowest rate constant. k' can be calculated from the terminal slope of Cp versus time on semi-log graph paper.

**Equation 30.4.3 AUMC for the last segment from t _{last} to infinity**

where k' is the slowest rate constant. k' can be calculated from the terminal slope of **Cp versus time** on semi-log graph paper.

**Equation 30.4.4 Mean Resident Time (MRT)**

**Equation 30.4.5 Clearance (CL)**

**Equation 30.4.6 Steady State Apparent Volume of Distribution, V _{ss}**

Last update: Thu 19 Jan 2012 09:10:00 am