Timehr |
Cpmg/L |
ΔAUCmg.hr/L |
AUCmg.hr/L |
Cp • tmg.hr/L |
ΔAUMCmg.hr ^{2}/L |
AUMCmg.hr ^{2}/L |

0 | 7.37 | 0 | 0 | 0 | 0 | 0 |

0.25 | 4.58 | 1.49 | 1.49 | 1.15 | 0.143 | 0.143 |

0.5 | 3.49 | 1.01 | 2.5 | 1.75 | 0.361 | 0.504 |

0.75 | 3.02 | 0.814 | 3.32 | 2.27 | 0.501 | 1.01 |

1 | 2.77 | A | C | 2.77 | 0.629 | 1.64 |

1.25 | 2.6 | B | 4.71 | 3.25 | 0.753 | 2.39 |

1.5 | 2.46 | 0.633 | 5.34 | 3.69 | D | F |

2 | 2.22 | 1.17 | 6.51 | 4.44 | E | 5.29 |

4 | 1.5 | 3.72 | 10.2 | 6 | 10.4 | 15.7 |

6 | 1.01 | 2.51 | 12.7 | 6.06 | 12.1 | 27.8 |

9 | 0.563 | 2.36 | 15.1 | 5.07 | 16.7 | 44.5 |

12 | 0.313 | 1.31 | 16.4 | 3.76 | 13.2 | 57.7 |

24 | 0.0298 | 2.06 | 18.5 | 0.715 | 26.8 | 84.5 |

Infinity | 0 | G | H | 0 | I | J |

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**Equation 30.4.1 AUC for the segment from i-1 to i**

**Equation 30.4.2 AUC for the last segment from t _{last} to infinity**

where k' is the slowest rate constant. k' can be calculated from the terminal slope of Cp versus time on semi-log graph paper.

**Equation 30.4.3 AUMC for the last segment from t _{last} to infinity**

where k' is the slowest rate constant. k' can be calculated from the terminal slope of **Cp versus time** on semi-log graph paper.

**Equation 30.4.4 Mean Resident Time (MRT)**

**Equation 30.4.5 Clearance (CL)**

**Equation 30.4.6 Steady State Apparent Volume of Distribution, V _{ss}**

Last update: Thu 19 Jan 2012 09:10:00 am