Timehr |
Cpmg/L |
ΔAUCmg.hr/L |
AUCmg.hr/L |
Cp • tmg.hr/L |
ΔAUMCmg.hr ^{2}/L |
AUMCmg.hr ^{2}/L |

0 | 19.6 | 0 | 0 | 0 | 0 | 0 |

0.25 | 13.9 | 4.19 | 4.19 | 3.48 | 0.434 | 0.434 |

0.5 | 11.4 | 3.16 | 7.35 | 5.7 | 1.15 | 1.58 |

0.75 | 10.1 | 2.69 | 10 | 7.58 | 1.66 | 3.24 |

1 | 9.44 | A | C | 9.44 | 2.13 | 5.37 |

1.25 | 8.97 | B | 14.8 | 11.2 | 2.58 | 7.95 |

1.5 | 8.6 | 2.2 | 17 | 12.9 | D | F |

2 | 7.98 | 4.15 | 21.1 | 16 | E | 18.2 |

4 | 5.99 | 14 | 35.1 | 24 | 39.9 | 58.1 |

6 | 4.51 | 10.5 | 45.6 | 27.1 | 51 | 109 |

9 | 2.94 | 11.2 | 56.8 | 26.5 | 80.3 | 189 |

12 | 1.91 | 7.28 | 64 | 22.9 | 74.1 | 263 |

24 | 0.346 | 13.5 | 77.6 | 8.3 | 187 | 451 |

Infinity | 0 | G | H | 0 | I | J |

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**Equation 30.4.1 AUC for the segment from i-1 to i**

**Equation 30.4.2 AUC for the last segment from t _{last} to infinity**

where k' is the slowest rate constant. k' can be calculated from the terminal slope of Cp versus time on semi-log graph paper.

**Equation 30.4.3 AUMC for the last segment from t _{last} to infinity**

where k' is the slowest rate constant. k' can be calculated from the terminal slope of **Cp versus time** on semi-log graph paper.

**Equation 30.4.4 Mean Resident Time (MRT)**

**Equation 30.4.5 Clearance (CL)**

**Equation 30.4.6 Steady State Apparent Volume of Distribution, V _{ss}**

Last update: Thu 19 Jan 2012 09:10:00 am