Timehr |
Cpmg/L |
ΔAUCmg.hr/L |
AUCmg.hr/L |
Cp • tmg.hr/L |
ΔAUMCmg.hr ^{2}/L |
AUMCmg.hr ^{2}/L |

0 | 2.63 | 0 | 0 | 0 | 0 | 0 |

0.25 | 2.06 | 0.586 | 0.586 | 0.515 | 0.0644 | 0.0644 |

0.5 | 1.73 | 0.474 | 1.06 | 0.865 | 0.173 | 0.237 |

0.75 | 1.54 | 0.409 | 1.47 | 1.16 | 0.253 | 0.489 |

1 | 1.42 | A | C | 1.42 | 0.322 | 0.811 |

1.25 | 1.33 | B | 2.18 | 1.66 | 0.385 | 1.2 |

1.5 | 1.26 | 0.324 | 2.51 | 1.89 | D | F |

2 | 1.15 | 0.603 | 3.11 | 2.3 | E | 2.69 |

4 | 0.829 | 1.98 | 5.09 | 3.32 | 5.62 | 8.3 |

6 | 0.601 | 1.43 | 6.52 | 3.61 | 6.92 | 15.2 |

9 | 0.371 | 1.46 | 7.98 | 3.34 | 10.4 | 25.6 |

12 | 0.229 | 0.9 | 8.88 | 2.75 | 9.13 | 34.8 |

24 | 0.0333 | 1.57 | 10.4 | 0.799 | 21.3 | 56.1 |

Infinity | 0 | G | H | 0 | I | J |

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**Equation 30.4.1 AUC for the segment from i-1 to i**

**Equation 30.4.2 AUC for the last segment from t _{last} to infinity**

where k' is the slowest rate constant. k' can be calculated from the terminal slope of Cp versus time on semi-log graph paper.

**Equation 30.4.3 AUMC for the last segment from t _{last} to infinity**

where k' is the slowest rate constant. k' can be calculated from the terminal slope of **Cp versus time** on semi-log graph paper.

**Equation 30.4.4 Mean Resident Time (MRT)**

**Equation 30.4.5 Clearance (CL)**

**Equation 30.4.6 Steady State Apparent Volume of Distribution, V _{ss}**

Last update: Thu 19 Jan 2012 09:10:00 am