Timehr |
Cpmg/L |
ΔAUCmg.hr/L |
AUCmg.hr/L |
Cp • tmg.hr/L |
ΔAUMCmg.hr ^{2}/L |
AUMCmg.hr ^{2}/L |

0 | 0.502 | 0 | 0 | 0 | 0 | 0 |

0.25 | 0.367 | 0.109 | 0.109 | 0.0918 | 0.0115 | 0.0115 |

0.5 | 0.304 | 0.0839 | 0.193 | 0.152 | 0.0305 | 0.0419 |

0.75 | 0.271 | 0.0719 | 0.264 | 0.203 | 0.0444 | 0.0863 |

1 | 0.251 | A | C | 0.251 | 0.0568 | 0.143 |

1.25 | 0.238 | B | 0.391 | 0.298 | 0.0686 | 0.212 |

1.5 | 0.227 | 0.0581 | 0.449 | 0.341 | D | F |

2 | 0.21 | 0.109 | 0.558 | 0.42 | E | 0.482 |

4 | 0.156 | 0.366 | 0.924 | 0.624 | 1.04 | 1.53 |

6 | 0.116 | 0.272 | 1.2 | 0.696 | 1.32 | 2.85 |

9 | 0.0743 | 0.285 | 1.48 | 0.669 | 2.05 | 4.89 |

12 | 0.0476 | 0.183 | 1.66 | 0.571 | 1.86 | 6.75 |

24 | 0.00802 | 0.334 | 2 | 0.192 | 4.58 | 11.3 |

Infinity | 0 | G | H | 0 | I | J |

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**Equation 30.4.1 AUC for the segment from i-1 to i**

**Equation 30.4.2 AUC for the last segment from t _{last} to infinity**

where k' is the slowest rate constant. k' can be calculated from the terminal slope of Cp versus time on semi-log graph paper.

**Equation 30.4.3 AUMC for the last segment from t _{last} to infinity**

where k' is the slowest rate constant. k' can be calculated from the terminal slope of **Cp versus time** on semi-log graph paper.

**Equation 30.4.4 Mean Resident Time (MRT)**

**Equation 30.4.5 Clearance (CL)**

**Equation 30.4.6 Steady State Apparent Volume of Distribution, V _{ss}**

Last update: Sat 28 Nov 2015 09:52:07 am