Timehr |
Cpmg/L |
ΔAUCmg.hr/L |
AUCmg.hr/L |
Cp • tmg.hr/L |
ΔAUMCmg.hr ^{2}/L |
AUMCmg.hr ^{2}/L |

0 | 4.63 | 0 | 0 | 0 | 0 | 0 |

0.25 | 3.75 | 1.05 | 1.05 | 0.938 | 0.117 | 0.117 |

0.5 | 3.32 | 0.884 | 1.93 | 1.66 | 0.325 | 0.442 |

0.75 | 3.09 | 0.801 | 2.73 | 2.32 | 0.497 | 0.939 |

1 | 2.95 | A | C | 2.95 | 0.658 | 1.6 |

1.25 | 2.84 | B | 4.21 | 3.55 | 0.813 | 2.41 |

1.5 | 2.76 | 0.7 | 4.91 | 4.14 | D | F |

2 | 2.61 | 1.34 | 6.25 | 5.22 | E | 5.71 |

4 | 2.12 | 4.73 | 11 | 8.48 | 13.7 | 19.4 |

6 | 1.72 | 3.84 | 14.8 | 10.3 | 18.8 | 38.2 |

9 | 1.25 | 4.46 | 19.3 | 11.3 | 32.4 | 70.6 |

12 | 0.916 | 3.25 | 22.5 | 11 | 33.4 | 104 |

24 | 0.261 | 7.06 | 29.6 | 6.26 | 104 | 207 |

Infinity | 0 | G | H | 0 | I | J |

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**Equation 30.4.1 AUC for the segment from i-1 to i**

**Equation 30.4.2 AUC for the last segment from t _{last} to infinity**

where k' is the slowest rate constant. k' can be calculated from the terminal slope of Cp versus time on semi-log graph paper.

**Equation 30.4.3 AUMC for the last segment from t _{last} to infinity**

where k' is the slowest rate constant. k' can be calculated from the terminal slope of **Cp versus time** on semi-log graph paper.

**Equation 30.4.4 Mean Resident Time (MRT)**

**Equation 30.4.5 Clearance (CL)**

**Equation 30.4.6 Steady State Apparent Volume of Distribution, V _{ss}**

Last update: Thu 19 Jan 2012 09:10:00 am