Timehr |
Cpmg/L |
ΔAUCmg.hr/L |
AUCmg.hr/L |
Cp • tmg.hr/L |
ΔAUMCmg.hr ^{2}/L |
AUMCmg.hr ^{2}/L |

0 | 1.17 | 0 | 0 | 0 | 0 | 0 |

0.25 | 0.816 | 0.248 | 0.248 | 0.204 | 0.0255 | 0.0255 |

0.5 | 0.668 | 0.186 | 0.434 | 0.334 | 0.0673 | 0.0928 |

0.75 | 0.599 | 0.158 | 0.592 | 0.449 | 0.0979 | 0.191 |

1 | 0.561 | A | C | 0.561 | 0.126 | 0.317 |

1.25 | 0.534 | B | 0.874 | 0.668 | 0.154 | 0.471 |

1.5 | 0.512 | 0.131 | 1 | 0.768 | D | F |

2 | 0.475 | 0.247 | 1.25 | 0.95 | E | 1.08 |

4 | 0.354 | 0.829 | 2.08 | 1.42 | 2.37 | 3.45 |

6 | 0.264 | 0.618 | 2.7 | 1.58 | 3 | 6.45 |

9 | 0.17 | 0.651 | 3.35 | 1.53 | 4.67 | 11.1 |

12 | 0.11 | 0.42 | 3.77 | 1.32 | 4.28 | 15.4 |

24 | 0.0188 | 0.773 | 4.54 | 0.451 | 10.6 | 26 |

Infinity | 0 | G | H | 0 | I | J |

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**Equation 30.4.1 AUC for the segment from i-1 to i**

**Equation 30.4.2 AUC for the last segment from t _{last} to infinity**

where k' is the slowest rate constant. k' can be calculated from the terminal slope of Cp versus time on semi-log graph paper.

**Equation 30.4.3 AUMC for the last segment from t _{last} to infinity**

where k' is the slowest rate constant. k' can be calculated from the terminal slope of **Cp versus time** on semi-log graph paper.

**Equation 30.4.4 Mean Resident Time (MRT)**

**Equation 30.4.5 Clearance (CL)**

**Equation 30.4.6 Steady State Apparent Volume of Distribution, V _{ss}**

Last update: Thu 19 Jan 2012 09:10:00 am