Timehr |
Cpmg/L |
ΔAUCmg.hr/L |
AUCmg.hr/L |
Cp • tmg.hr/L |
ΔAUMCmg.hr ^{2}/L |
AUMCmg.hr ^{2}/L |

0 | 6.76 | 0 | 0 | 0 | 0 | 0 |

0.25 | 4.37 | 1.39 | 1.39 | 1.09 | 0.137 | 0.137 |

0.5 | 3.22 | 0.949 | 2.34 | 1.61 | 0.338 | 0.474 |

0.75 | 2.65 | 0.734 | 3.07 | 1.99 | 0.45 | 0.924 |

1 | 2.35 | A | C | 2.35 | 0.542 | 1.47 |

1.25 | 2.18 | B | 4.27 | 2.73 | 0.634 | 2.1 |

1.5 | 2.07 | 0.531 | 4.8 | 3.11 | D | F |

2 | 1.92 | 0.998 | 5.79 | 3.84 | E | 4.57 |

4 | 1.52 | 3.44 | 9.23 | 6.08 | 9.92 | 14.5 |

6 | 1.2 | 2.72 | 12 | 7.2 | 13.3 | 27.8 |

9 | 0.846 | 3.07 | 15 | 7.61 | 22.2 | 50 |

12 | 0.596 | 2.16 | 17.2 | 7.15 | 22.1 | 72.1 |

24 | 0.147 | 4.46 | 21.6 | 3.53 | 64.1 | 136 |

Infinity | 0 | G | H | 0 | I | J |

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**Equation 30.4.1 AUC for the segment from i-1 to i**

**Equation 30.4.2 AUC for the last segment from t _{last} to infinity**

where k' is the slowest rate constant. k' can be calculated from the terminal slope of Cp versus time on semi-log graph paper.

**Equation 30.4.3 AUMC for the last segment from t _{last} to infinity**

where k' is the slowest rate constant. k' can be calculated from the terminal slope of **Cp versus time** on semi-log graph paper.

**Equation 30.4.4 Mean Resident Time (MRT)**

**Equation 30.4.5 Clearance (CL)**

**Equation 30.4.6 Steady State Apparent Volume of Distribution, V _{ss}**

Last update: Thu 19 Jan 2012 09:10:00 am