Simulation of Drug Concentration - Multiple Dose

Simulation of Drug Concentration
Multiple Dose
Two Compartment Model

A patient is to receive lidocaine by IV bolus (three doses possible) and a continuous IV infusion to achieve and maintain drug concentrations between 2 and 6 mg/L for 120 minutes. For this patient use parameters value of kel, k12, k21 and V1 of 0.0264 min^-1, 0.0783 min^-1, 0.0408 min^-1, and 38.5 L, respectively.

Some Equations

Equation 30.5.1 Loading Dose using V₁

Equation 30.5.2 Maintenance Infusion Rate using V₁ or Clearance

Equation 30.5.3 Drug Concentration after an IV Bolus Dose

Equation 30.5.4 Drug Concentration after an IV continuous Infusion

Version (a) was derived from the Laplace prepared by convolution with roots 0, -α and β. Version (b) was derived by rearranging version (a). In version (c) clearance, CL, replaces V₁ • kel.

Last update: Fri 14 Nov 2003 05:30:47 pm

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Parameter	Your answers
First Bolus Dose	mg
Second Bolus Dose	mg	at min
Third Bolus Dose	mg	at min
Maintenance Infusion	mg/min

Simulation of Drug ConcentrationMultiple DoseTwo Compartment Model

Some Equations

Simulation of Drug Concentration
Multiple Dose
Two Compartment Model