Research interests include the study of pharmacokinetic models; especially physiologically based models, models involving protein binding, pharmacodynamic models and the development of computer programs for pharmacokinetic analysis. Recent work has included the development of models for cephalosporin and sulfonamide disposition including protein binding; oral and Intranasal administration of selected drugs and comparison with IV administration; and the influence of zero gravity of drug absorption and disposition. Computer programs include BOOMER a general purpose non-linear regression and simulation program written in FORTRAN for the Macintosh and IBM PC desktop computers. Ancillary to the study of pharmacokinetic models is the development of drug analysis techniques, especially high pressure liquid chromatography. Use of the Internet as a research and teaching resource is a major interest.