PharmPK Discussion - Analytical method of nitroglycerin

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On 19 Sep 2007 at 14:34:21, "Yuvraj Monga" (yuvrajmonga.at.gmail.com) sent the message


I have a query:
what is the acceptable/ideal analytical method for oral nitroglycerin
sustained release prepration to conduct Bioavailabilty studies. Is it
GC or GCMS or LCMS

Kindly help
Dr Yuvraj arora
M.D. pharmacology

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On 22 Sep 2007 at 21:55:35, Farzad Kobarfard (farzadkf.aaa.yahoo.com) sent the message


Dear Yuvraj

As far as I know the best method is GC/MS since you have to look for
1,2-dinitro and/or 1,3-dinitro metabolites of TNG in plasma, not TNG
itself.
Please let me know if you got any other info about it.

Farzad Kobarfard

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