PharmPK Discussion - Assay of Amodiaquine HCL from Urine Samples

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On 9 Mar 2007 at 09:39:20, BEDIAKO ANGO (bediakoango.aaa.yahoo.com) sent the message


I am a graduate student currently pursuing pharmacokinetic
investigation of Amodiaquine Hydrochloride in black subjects,
specifically in Ghana. However I am encountering a problem as to
come up with a suitable assay method for both Amodiaquine HCL and
des- ethylamodiaquine from urine samples. Note that owing to
inadequate resources in this part of the world I have been
compelled to limit my research to only urine samples as I can't get
access to plasma (blood) samples. I would therefore be most
grateful if you could furnish me with a suitable analytical method
for the assay of both amodiaquine and its metabolite
desethylamodiaquine. Looking forward to hear favourably from you
soon. Thanks and goodbye.

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