PharmPK Discussion - Atorvastatin assay BE study

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On 4 Aug 2007 at 19:14:31, "Daniel B. Schere" (schere.aaa.fibertel.com.ar) sent the message


Does anyone know if we can use a HPLC UV method to perform a 40 mg
atorvastatin bioequivalence protocol, and if there is a HPLC UV
procedure for it?Thanks

Daniel Schere
schere.aaa.fibertel.com.ar

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On 7 Aug 2007 at 13:14:20, Anders Aasberg (anders.asberg.-a-.farmasi.uio.no) sent the message


The following message was posted to: PharmPK

Dear Daniel Schere,
You will need to use MS detection. Also look into the "problem" that =20
atorvastatin is present in both an acid and a lactone form in vivo.

Best regards,
Anders =C5sberg
anders.asberg.-a-.farmasi.uio.no

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