PharmPK Discussion - Bioavailability with high first pass effect from sustained release formulation

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On 11 Jul 2007 at 14:28:31, dubeyr.-a-.drreddys.com sent the message


Dear All

Is there any published report indicating that controlled/slow release
of a
drug that undergoes significant first pass effect in liver as well as is
labile to presystemic metabolism in GIT (by esterases, microflora as
well
as epithelial metabolism) will actually decrease the bioavailability
of the
drug.
Pls provide the reference and if possible, a copy of the article.
Regards
Rajesh

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