Information provided by the author.
This new and expanded edition differs substantially from the first edition in that pharmacokinetic and pharmacodynamic theory as well as modeling concepts are expanded. Detailed sections on NCA, non-linear kinetics (capacity, time, flow, and binding), turnover concepts, pulsative functions, push-and-pull and precursor models, binding- and displacement models, toxicokinetic models and determination of initial parameter estimates for complex models are included. PART ONE of the text is a basic introduction to pharmacokinetic and pharmacodynamic modeling principles and can be understood by scientists with very little formal training in this area. Complex mathematics are minimized. Extensive graphical presentations accompany the theory. This enables the scientist to conceptualize the underlying principles, such as clearance, potency, tolerance weighting, and search algorithms. Issues on program validation are also discussed. PART TWO is aimed to illustrate the application of the concepts to specific modeling situations commonly encountered at the drug industry and in research labs. Several new exciting data sets on tolerance-rebound, dose-response-time models, bacterial growth model, turnover, non-linear kinetics, oscillating input functions, and toxicokinetics are also solved and discussed in this section. The book bridges the gap between standard texts in pharmacokinetics, pharmacology and numerical analysis, and provides unique insight into the field of pharmacometrics in an easy to understand manner.
The book + all example files on a diskette is available from the Swedish Pharmaceutical Press (FAX +46-(0)8-14 95 80), http://www.swepharm.se/ or D. Weiner, SCI, Inc. (FAX 919-859-6871, phone: 919-859-6868 or E-mail: 75450.3171@compuserve.com) for USD 60