Investigate the effect of changing k_{0}, k_{H+}, k_{OH-}, k_{a}, k_{b} and C_{a} values on the semi-log plot of observed k' versus pH. Explore the equation by changing the parameter values.

The observed first order rate constant k' may be calculated a function of the specific reaction rate, k_{0}, the specific acid-base catalytic coefficients, k_{H+} and k_{OH-}, and the general acid-base catalytic coefficients, k_{a} and k_{b}, according to Equation 1.

Equation 1. Observed rate constant versus pH

k_{0}, the specific reaction rate is independent of pH

With specific acid catalysis of the reaction k_{H+} is multiplied by the concentration of hydrogen ion, H^{+}.

Specific base catalysis is included by multiplying k_{OH-} by the concentration of hydroxyl ion concentration, OH^{-}.

General acid catalysis is included in equation 1 by multiplying k_{a} by the concentration of general acid, HA, given by equation 2.

**Equation 2. Concentration of the acid form of a monoprotic acid**

General base catalysis is included in equation 1 by multiplying k_{b} by the concentration of general base, A^{-}, given by equation 3.

**Equation 3. Concentration of the base form of a monoprotic acid**

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