=> To understand the assumptions associated with the one compartment model
=> To understand the properties of first order kinetics and linear models
=> To write the differential equations for a simple pharmacokinetic model
=> To recognize and use the integrated equations for a one compartment linear model
=> To define, use, and calculate the parameters, kel, t1/2, V, and AUC as they apply to a one compartment linear model
Definition: Pharmacokinetics is the study of drug and/or metabolite kinetics in the body. It deals with a mathematical description of the rates of drug movement into, within and exit from the body. It also includes the study of drug metabolism or biotransformation rates. The body is a very complex system and a drug undergoes many steps as it is being absorbed, distributed through the body, metabolized or excreted (ADME).
Diagram IV-1, Drug Disposition
The drug also interacts with receptors and causes therapeutic and/or toxic responses. Although the details of drug kinetics are complicated it is fortunate that we can often approximate drug kinetic processes using "simple" mathematical models.
Copyright 2001 David W.A. Bourne