fenormal = 0.75
Thus: kenormal = 0.18 x 0.75 = 0.135 hr-1
and kmnormal = 0.18 - 0.135 = 0.045 hr-1
Now kerenal patient = kenormal/5 = 0.135/5 = 0.027 hr-1
and kmrenal patient = kmnormal = 0.045 hr-1
kelrenal patient = 0.027 + 0.045 = 0.072 hr-1
t1/2 went from 3.85 hr to 9.63 hr
Parameter | Value | Unit |
kerenal patient | 0.027 | hr-1 |
kelrenal patient | 0.072 | hr-1 |