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NOTE: Missing data means that the Amount Remaining to be Excreted method cannot be used. Thus, need to plot R/E versus midpoint time
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Plot U/
t versus tmidpoint on semi-log graph paper.
Intercept by inspection after putting a line through the data on semi-log graph paper = 78.4 mg/hr
kel from the -ve slope of ln-linear line through the data. Note the R/E on the line at 5 hours is 17.6. NOTE: This will depend on where you put the line. Everyone may put the line in a different place.
kel = (ln 78 - ln 0.23)/20 = 0.291 hr-1
Since the Intercept = ke x Dose = 78.4 = ke x 400
ke = 78.4/400 = 0.196 hr-1
Since km = kel - ke = 0.291 - 0.196 = 0.095 hr-1
fe = ke/kel = 0.196/0.291 = 0.674
fm = km/kel = 0.095/0.291 = 0.326
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